Welcome to SyBil-AA

the EU-funded Horizon2020 project about Systems Biology of Alcohol Addiction:
Modeling and validating disease state networks in human and animal brains for
understanding pathophysiology, predicting outcomes and improving therapy.


Relapse to alcohol drinking – a problem of network communication


An assembly of leading researchers from many different disciplines will provide a foundation to understand the networks within the brain and to find ways of guiding these networks toward a more healthy state.

Alcoholism: a multifactorial and extremely complex disease
Converging ideas from clinicians with techniques of animal researchers
Complex dynamic interactions require very sophisticated mathematical tools
A new technology: deep transcranial magnetic stimulation (deep TMS)

It is not enough to investigate one system level at a time – we have to combine the levels to get the entire picture, using a systems medicine approach.

In clinical studies, many questions cannot be answered for practical and ethical reasons. The interaction with animal researchers will help fill these knowledge gaps.

Basic research must be combined with mathematical analysis, to build hypotheses, and to test them – it is exciting to see where this will lead us.

Application of deep TMS to stimulate the insula – a region which is very important in the craving for drugs – can help us understand brain activity patterns in alcoholism