Sex and gender aspects
The prevalence of alcohol addiction differs strongly in male and women, about 5 % of male and 1 % women adult population are afflicted by the disorder in Europe.
Our previous studies have included both sexes and gender was included as a factor in the analysis without showing any prominent effects. All studies planned here will be sufficiently powered to allow the analysis of gender and sex effects. If we find indications for sex-specific main effects or interactions in the present studies, we will set up experiments in both humans and animals that will specifically explore such effects in male and female populations.
In terms of sex-related differences in animals we have implemented a guest-chair at the Central Institute of Mental Health: Jill Becker from the University of Michigan is a world leader in the studies of gender differences in drugs of abuse and will fill in this guest-chair from 2015-2020. She will advise all consortia members involved in animal work in respect to sex-related mechanisms and experiments.
Jill Becker, University of Michigan